As today I saw a @binbinhfr question here:   I decide to post here this 2 following examples, which shows how to use GUICoordMode=2 + GUISetCoord()   Simple example: #include <GUIConstantsEx.au3> Example() Func Example() Opt("GUICoordMode", 2) ; relative to cell mode GUICreate("My GUI Set Coord", 500, 200) GUISetCoord(20, 50) ; move the current anchor position to a precise point (20,50) GUIC