flawless IPC in an overwhelmed PC

[argumentum]

so in https://www.autoitscript.com/forum/topic/193254-solved-ipc-between-system-and-user/ I asked around about IPCs and got all the answers I was looking for.

Now the question is: what IPC is most "resilient" on an overwhelmed PC, meaning, the CPU is at 100%, memory is top out and, as is always, need to rely on the IPC.
..and all this happened because I open over 100 GUIs at once 😜
..but it happens sporadically on low CPU or memory demand anyways.
..should I sleep() some time before running another instance ?

I did not know if to make the question in technical, chat, ..or here. So it's here.   

Since you will ask what I've tried, I've used the IPC from the Fork UDFish ( WM_COPYDATA that can do Admin/user mix ) and the FMIPC file mapping,  that work under the same conditions.

So, how do you handle IPC if it fails ?