Here a small function to mark a region on the desktop and capture that region to a bitmap handle or to the clipboard: #include-once #include <Clipboard.au3> #include <GUIConstantsEx.au3> #include <MsgBoxConstants.au3> #include <WinAPIGdi.au3> #include <WindowsConstants.au3> #Region Example ;capture manual coordinates FileDelete(@ScriptDir & "\Captured.bmp") Global $hHBitmap = _WinAPI_MarkScreenRegionAnd